He was the toughest, strongest man I've ever known and by the time he passed away he was a thin withered husk. The case records of patients with known germ cell tumours (GCTs) within the Anglian Germ Cell Cancer Group database between January 2005 and March 2011 were reviewed retrospectively. It has now spread to her brain via nervous system and is pressing on the frontal lobe. Things that make you say "What the F*ck". Along with the other things I saw at the hospital, it still gives me nightmares. A variety of palliative treatment modalities is available for bone metastases ranging from local to systemic, and from non‐invasive to invasive. I never said it in my original post, but cancer fucking sucks y'all. I discussed my dad’s case in this thread. consensual internet hug. Forty‐three patients (57.3%) also had extra‐osseous metastases. Bone metastases, or osseous metastatic disease, is a category of cancer metastases that results from primary tumor invasion to bone.Bone-originating primary tumors such as osteosarcoma, chondrosarcoma, and Ewing's sarcoma are rare. The clinical treatment of bone metastasis from breast cancer is currently based on the systemic administration of antiresorptive agents, radiopharmaceuticals, and/or local treatments such as radiation therapy, radiofrequency ablation and surgery. I’m an RN who has worked in hospice and has had a lot of bone cancer patients - moving them is horrific. We report a case of bone metastases from bronchogenic carcinoma in a patient with TS bone changes. He lasted only three months from diagnoses. Most of the patients received radiotherapy, chemotherapy or both, but 25 patients (33.3%) received palliative care only. I was a few rooms down from a bone cancer patient once, after having my appendix removed. It’s the f’kin worst. My dad just died from this. Reddit; Wechat; SUMMARY. r/Radiology. The findings were published in … We were eight at the time. Bone metastases were found in the spine (46.7%) and pelvis (42.7%). Reddit; Wechat; Abstract. bone metastases) are common and result in significant morbidity in patients with metastatic disease.Although the diagnosis is often straightforward, especially as in many cases there is a well-documented history of metastatic malignancy, sometimes they may mimic benign disease or other primary malignancies. Bone metastases in patients with metastatic renal cell carcinoma (mRCC) do not independently affect oncologic outcomes or survival, according to data presented at SUO 2020, a … Google PET scan bone mets. It’s cruel and horrific. The sites of bone metastases were the vertebrae (15/19, 79%), pelvis (3/19, 16%), ribs (3/19, 16%) and femur (2/19, 11%). Bisphosphonates were given as palliative therapy to 25 patients (33.3%). I hope I never meet any of you or your families. Only radiation and death are the way around the pain. When I was in medical high school we had to practise at the Oncology department. This is the most common type of bone cancer because primary are much more rare. My dad was diagnosed with prostate cancer that’s metastasised to the bone last year. There is so much worse than death. Introduction In solid tumours, bone metastasis most commonly happen in prostate, breast and lung cancers. Close. Skeletal-related events and pattern of care. As well as being in his lymph nodes and bladder. One day we had to attend an hour on the autopsy table where we had a guy with metastatic bone cancer that OD-ed with morphine (maybe even euthanised by a doctor or nurse). My dad has lung cancer with several metastases (lung and lower spine mainly). Cookies help us deliver our Services. Hopefully they were able to make him comfortable. Metastases preferentially target the lymph nodes, lung, liver, or bone. The clinical records, scintigrams, radiographic skeletal surveys, and bone marrow aspiration and trephine results of 30 children with neuroblastoma were reviewed to determine the relationship between the result of the scintigram and the clinical outcome of the patient. 1, 2 As metastases occur, the normally tempered osteoclasts are transformed into unruly bullies, proliferating and resorbing bone with abandon. Other autopsy studies report bone me- tastases in 47 to 85 per cent of women dying from breast cancer, in 33 to 85 per cent of patients with prostatic cancer, and in 32 to 60 per cent of patients with lung cancer (86). Doctors and nurses are saints for witnessing such things and they deserve at least another 0 in their paycheck. Likely better than our best science if we were to be honest. log in sign up. Les métastases osseuses peuvent causer une morbidité importante, notamment de la douleur, des difficultés ambulatoires et une indépendance fonctionnelle réduite. Bone metastases in patients with solid tumours (ST) and bone lesions in patients with haematological malignancies (HM) are common. I remember vividly the look on his face, the last time I went to see him. Whereas an increasing body of mechanistic studies expanded our understanding on bone tropism, they also revealed complexity across the bone lesions originated from different cancer types. A consecutive series of 95 patients with hypernephroma was studied retrospectively after it was clinically suspected that there was a propensity for this tumor to metastasize to the scapula. Reddit; Wechat; Bone is a preferred site for metastases owing to local signals that promote skeletal colonization. Google PET scan bone mets. Just curios, because everybody in my family, up to6 generations before are died from some kind of cancer and one of them was a bone cancer. Bone metastases develop in approximately 30% to 40% of people with advanced NSCLC, with metastases either present at the time of diagnosis or developing during the course of the neoplastic disease. What do you do? Cookies help us deliver our Services. Citing Literature. I’ve had patients with this diagnosis but... thought of it as like, tumors growing on the bones? User account menu. Reddit; Wechat; Abstract. Press question mark to learn the rest of the keyboard shortcuts. Not only for myself, but for the people who have to watch, like I did. This study evaluated the number and timing of SREs from case studies to identify these factors. In vertebra spine, bone metastasis can cause catastrophic compression fracture (bone fracture that compresses the spinal cord) which leads to: paraplegia (paralysis of both lower legs) quadriplegia (paralysis of both upper and lower limbs if compression fracture happened at higher… Unlike hematological malignancies that originate in the blood and form non-solid tumors, bone metastases generally arise from epithelial tumors and form a … As reported above, bone metastases are most frequently located in the axial skeleton, where an overlay of structures hampers the detection of decent findings when using XR, but detection of skeletal metastases in extremities is a valid method as no overlap of other structures or bones is present . Extensive bone cancer metastases!! Extensive bone cancer metastases!! Abstract Purpose: To evaluate whether enhancement on serial dynamic gadolinium‐enhanced abdominal–pelvic MR imaging (DCE‐MRI) can determine the acuity of bone metastases… Oh wow. This makes me so worried. By using our Services or clicking I agree, you agree to our use of cookies. Associated skeletal‐related events (SREs) cause severe pain, reduced quality of life and place a burden on health care resources. Extensive bone cancer metastases!! She moaned in agony constantly. Close. We know it’s a matter of time before something else fractures. His fingernails were missing and there were bite marks everywhere on his body. September 13, 2019. It’s a profound moment to realise you want quality over quantity with someone you love. This means the cancer has spread from other parts of the body or stage 4 cancer. It wasn't a whiny, complaining type of moaning. Pinterest Reddit Tumblr Digg More. Sclerotic and lytic bone changes of tuberous sclerosis (TS) can mimic bone metastases. Reddit; Wechat; Abstract. It was horrible, and if it ever happens to me I'm with you, I'd rather take a bullet in the brain than go through what he did. Metastasis to bone from carcinoma of the thyroid was noted in 33 (12.7%) of 259 patients referred to the Nuclear Medicine Section of the University of California Medical Center, San Francisco from 1945 through 1964. She is losing her mind, voice and ability to speak/understand. Bone metastases have the potential to cause significant morbidity including pain, impairment of ambulation and reduced functional independence. Ten patients (53%) had solitary, and nine patients (47%) had multiple, sites of bone metastases. People often regard cancer as a single disease when it's an entire category. Reddit; Wechat; INTRODUCTION. I’m so sorry for your loss. He's been on keytruda for a while now and has been in a stable condition for the past months which I'm very thankful for . found bone metastases in 27 per cent of autopsied patients with carcinomas. X-rays showed holes throughout his bones. Both bone properties and the tumor-intrinsic traits are associated with the metastatic propensity to bone (i.e., the bone tropism). Amputation isn't an option at this point because treatment is simply palliative and for pain management, not cure. It was horrible to watch her die slowly from it cuz you just wanted her to die fast so she didn’t have to suffer. New comments cannot be posted and votes cannot be cast, More posts from the interestingasfuck community, Press J to jump to the feed. The pain is unending even when using extremely high doses of every narcotic in my arsenal. Is the contrast media responsible for the coloration? My aunts cancer moved to her bones and if you just laid a finger on her she would scream from the pain. Bone scintigraphy and magnetic resonance imaging are useful in distinguishing the TS bone lesions from bone metastases. This makes it a lot scarier. I don't know your diagnosis, prognosis, or current health status. Reddit; Wechat; Abstract. I am with you. Objective. 6.1k points. Reddit; Wechat; Abstract. By using our Services or clicking I agree, you agree to our use of cookies. Sorry to hear it. Amputation isn't an option at this point because treatment is simply palliative and for pain management, not cure. Hypercalcemia was the most frequently observed SRE in the non-NPC patients … The mom of my gf is going through exactly what you mentioned right now. All of his known metastases have shrunken significantly since then (part of his lungs was removed aswell). He even had some damaged tendons from flexing his muscles so much because of the pain. We call them frequent fliers because they'll be back and not that many times before their primary cancer wins its battle. The pain he was in looked unbelievable. My grandpa died of the bone cancer you're talking about. I still think about her 20 years later. We describe three patients with multiple silent bone metastases exhibiting a fatty halo at MRI that coexisted with expansive bone lesions. Press question mark to learn the rest of the keyboard shortcuts. Reddit; Wechat; Abstract. That’s terrifying. A blessing really. 12 Osteoclasts are large, multinucleated cells with a specialized cell membrane (the “ruffled border”) that resorb bone, and osteoblasts are smaller, mononucleated cells that form new bone. Methods. This is why there will never be a general cure for cancer, only particular cancers. These tests may show bone metastases. INVESTIGATIONS ON the pathogenesis of cancer metastasis to bone have received increased attention by scientists worldwide. There were bone metastases at diagnosis (0.51%, 13/2550) or at relapse (0.24%, 6/2550). Bone is a frequent site of metastases in many cancers. Bone metastases are sometimes found because they cause problems, but in some cases, they’re found before you have any symptoms. 16. You could tell it was involuntary, and that she was consumed with misery. That is a kind of bone cancer. He was fourth stage when he was diagnosed. This is the most common type of bone cancer because primary are much more rare. Posted by. A look that implored me to help - yet there was no help I could offer. Bone‐modifying agents (BMAs) reduce the incidence of skeletal‐related events (SREs) and are thus recommended for breast cancer patients with bone metastases. • Posted by u/[deleted] 2 months ago. This is one of those things. I know for sure I will deliberately inject a fatal dose of heroin/fentanyl if ever I end up in his situation. To determine the characteristics of patients with germ cell cancer and bone metastases. Edit: Due to common repeated questions. Based on favorable experience in other cancers with bone metastases and the lack of effective treatment, we started to use zoledronic acid (ZA), a recently developed synthetic bisphosphonate drug, in the treatment of this disease. Not into the bones. The research team concluded that the B6Ca P line overcomes two critical limitations to study the skeletal metastasis of prostate cancer: PCa can now be studied in fully immunocompetent hosts and the injection produces bone metastases for scientists to study. I've never felt more sorry for a person in my life. Skeletal metastases (a.k.a. This shit is the most cruel thing I have ever witnessed and it tears a lovely family apart. I'm with you: Kill me. Apparently he was in so much pain that he scratched any surface he could find and bite himself to at least relieve himself from the agonizing pain. Yes, my 42 year old brother had the "opposite", multiple myeloma. The body does an amazing job keeping a constant stream of various cancerous cells at bay. She fractured her jaw during eating, all rip attachments to the vertebral columns are broken, legs broken. Malignancy (defined as metastatic disease) has been reported in nearly 5% of head and neck paragangliomas. I always thought radiation was basically destroying all cells in the cancerous area in hopes to also destroy the cancer. Palliative radiotherapy has proven to be successful in treating pain caused by metastatic lesions in any bone, and in treating neurological complaints caused by compression of the spinal cord due to lesions in the spinal column. occur when cancer cells break off from a primary tumor that is somewhere else in the body Fuck cancer. The treatment of bone metastases comprises a large part of the radiotherapy daily practice. They almost missed the fractures because of the cancer, and I know that eventually he’ll break something somewhere they can’t find or treat. Bone metastases were mainly localized to the spine (61%), pelvic bones (15%), ribs (8%) or other sites (16%), without significant differences between the NPC and the non-NPC patients. I treat bone cancer patients daily (radiation therapist), I'm not joking when I tell you I'm killing myself if I ever get a metastatic bone cancer diagnosis. Imaging of bone metastases may rely on nuclear medicine [bone scintigraphy or singlephoton emission computed tomography (SPECT), positron emission tomography (PET), PET-CT, or SPECT-CT], on radiograph-based technologies (radiographs and CT), and on MRI. People i work with shine like Christmas trees. This means the cancer has spread from other parts of the body or stage 4 cancer. Dr. Kenyon Meadows here, board-certified radiation oncologist with Southeast Georgia Health System Cancer Care Centers, and today’s video blog topic is bone metastases. Abstract Although bone marrow examination is a common procedure in the evaluation of patients with cancer, its role and contribution have been questioned in recent years. Bone Metastases. Is amputation a valid choice or does it spread quickly? Pain medicine cannot reach the pain. I'm also not a doctor, just a licensed radiation therapist in the midwest. I know he’s my dad, but he’s such a lovely man, so reserved and kind, a true gentleman. I'm specifically talking about bone metastasis. Bone‐targeted agents can reduce the risk of SREs. Reddit; Wechat; Summary. He’s only 65. , so is there any way to completely cure a cancer in a stage when rapid cell mutation already started?Also example of a opposite kind of bone cancer, this is a slow process, not like a just hole suddenly appeared in a bone? However, the risk factors for SREs during BMA treatment are not well‐understood. Reddit; Wechat; Abstract en. 16. Background. Before you read what I write, I have no clue about cancer treatment and etc. When literally a hole is punched in the bone. New comments cannot be posted and votes cannot be cast. Press J to jump to the feed. That is not a joke or embellishment. Somehow that makes it worse. 77. Patients and Methods . Bone metastases are a common clinical problem that is associated with the potential for significant symptoms such as pain, pathologic fracture, spinal cord compression, and hypercalcemia. The opposite is most painful. Background: Currently bisphosphonates are often administered to patients with osteolytic bone metastases from several neoplasms. Her last week has begun, the pain is extremely crazy and she is full on morphium if that even helps. Your doctor may do lab tests and imaging tests (like x-rays or bone scans) to see if and/or how far the cancer has spread. radiation and death are the way around the pain. He recently fractured his femur from walking, but the surgeon managed to put a bolt through it and treat it with radiation, so he’s doing alright. u/thellios. As someone with no knowledge on radiation or how it works, could you elaborate on how radiation helps with the pain? The cancer is in his spine, ribs, pelvis and thigh. Toxic chemo did him in, as he suffered a heart attack. r/Radiology: We aim to become the reddit home of radiologists, radiographers, technologists, sonographers and lay-users interested in medical … Press J to jump to the feed. Press question mark to learn the rest of the keyboard shortcuts. Prostate cancer bone metastases - 6 months after first meta. People i work with shine like Christmas trees. Crossposted by 2 months ago. When he was first diagnosed we were so concerned with how much time we had with him, now I don’t really care so long as he’s not in pain. 302 comments. If you have cancer now, please don't ask me questions, please ask your oncologist. My best mate died of it in 1988. Bone metastases can be classified as lytic, blastic, or mixed depending on the activity of tumor-stimulated host osteoclasts and osteoblasts. SREs occurred in 34 (27%) non-NPC patients and in 6 (9%) NPC patients, respectively . 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